| Season | 2005–06 |
|---|---|
| Champions | FC Sheriff Tiraspol |
| Relegated | none |
| Champions League | FC Sheriff Tiraspol |
| UEFA Cup | FC Nistru Otaci, FC Zimbru Chisinau |
| Intertoto Cup | FC Tiraspol |
| Matches played | 112 |
| Goals scored | 237 (2.12 per match) |
| Top goalscorer | Aliaksei Kuchuk, Sheriff (13) |
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← 2004–05
2006–07 →
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The 2005–06 season was the last to be played with eight teams, FC Sheriff Tiraspol winning their sixth consecutive league title.
| Pos | Club | P | W | D | L | GF | GA | Pts |
| 1 | FC Sheriff Tiraspol | 28 | 22 | 5 | 1 | 57 | 11 | 71 |
| 2 | FC Zimbru Chişinău | 28 | 15 | 8 | 5 | 47 | 20 | 53 |
| 3 | FC Tiraspol | 28 | 8 | 13 | 7 | 24 | 21 | 37 |
| 4 | CS Tiligul-Tiras Tiraspol | 28 | 7 | 13 | 8 | 22 | 23 | 34 |
| 5 | FC Nistru Otaci | 28 | 6 | 13 | 9 | 24 | 27 | 31 |
| 6 | FC Dacia Chişinău | 28 | 7 | 9 | 12 | 28 | 39 | 30 |
| 7 | FC Politehnica Chişinău | 28 | 5 | 10 | 13 | 18 | 37 | 25 |
| 8 | FC Dinamo Bender | 28 | 2 | 9 | 17 | 17 | 59 | 15 |
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